The statement you provided is accurate. Testolactone is indeed:

Non-selective: It inhibits all isoforms of the aromatase enzyme, not just the specific isoforms involved in estrogen production.
Irreversible: It binds covalently to the aromatase enzyme, permanently deactivating it.
A steroidal aromatase inhibitor: Its structure resembles that of steroids, allowing it to bind to the aromatase enzyme.
Effective in reducing estrogen levels: By inhibiting aromatase, it prevents the conversion of androstenedione to estrogen, leading to lower overall estrogen levels.
This information is helpful for understanding the mechanism of action of testolactone and its potential benefits for conditions such as breast cancer, gynecomastia, and precocious puberty. However, it’s important to remember that:

Testolactone’s non-selective nature can lead to unintended consequences like reduced bone density.
Its irreversible effect requires careful monitoring and consideration of potential side effects.
Alternative therapies with fewer side effects might be considered depending on the individual patient.
Therefore, while the statement is accurate, it’s crucial to have a comprehensive understanding of testolactone’s properties and potential drawbacks before considering its use for any medical condition.