Unfortunately, the information provided is incomplete and lacks context. To understand the statement and provide a meaningful response, I need more information. Please provide details about:

The purpose of determining the genotype frequencies: Is this part of a research study, a clinical trial, or individual patient analysis? Knowing the goal helps interpret the results.
The specific polymorphisms being analyzed: You mentioned CYP2D6, CYP3A5, CYP3A4 22, and CYP3A4 1B, but it’s unclear which specific variants within each gene are being investigated. Providing specific allele information is crucial for interpreting the genotype frequencies.
The population or sample size: Knowing the number of individuals studied helps assess the representativeness andgeneralizability of the data.
The method used for gene counting: Was DNA sequencing, genotyping assays, or other methods employed? Understanding the methodology ensures accurate interpretation of the results.
The interpretation of the genotype frequencies: What are the implications of these frequencies for drug metabolism, potential drug interactions, or other relevant outcomes? Providing context helps understand the significance of the findings.
Once you provide this information, I can analyze the statement and offer a comprehensive and informative response.